"We know that inflammation is one of the leading causes of premature ageing of the skin, so including an
ingredient that fought inflammation was important to us."
Margo Marrone
What is inflammaging?
Inflammaging is the combination of inflammation and ageing. A process that can occur when we don't nurture our skin and bodies with the nutrients they need.
When does inflammaging occur?
- when we consume processed foods
- chronic + oxidative stress
- obesity
- gut permeability
- chronic infections
- processed sugar
How to fight inflammaging with us
Our Clinically proven ingredient from Up-cycled Chios mandarins – CALmandrin™
The historic orchards on the Greek island of Chios are home to a traditional small distillery where both the juice and the peel of the Chios mandarins are used for the gentle distillation process of organic fragrance production.
The remaining nutrient-rich and thick peel pulp (pomace) is the raw material for producing the active ingredient CALMandrinTM, which we use in our products. This up-cycled and potent material (traditionally discarded) is rich with antioxidants and phytonutrients that are extracted through a gentle, water-based process. A hidden gem delivering a sustainable source and powerful antioxidant boost that help fight inflammaging.
What does that do for our products?
Calm redness, increase density and firmness of the skin and fight inflammaging!
Proven efficacy
In vitro:
- Reduction of inflammatory gene expression in keratinocytes
- Reduction of inflammation reaction induced by inflammatory keratinocyte secretion
- Reduction of protein carbonylation induced by inflammation in keratinocytes
- Increase in procollagen I secretion in keratinocytes
- Production of newly formed collagen in skin explants
In vivo:
- Reduction of skin redness
- Improvement of skin elasticity
- Improvement of skin firmness
- Improvement of skin density
Benefits of CALMandarinTM
- Calms irritated skin
- Soothes inflamed and reddened skin
- Promotes collagen production
- Improves skin firmness and skin density
Our co-founder Margo, who formulated all the products herself, will ONLY use natural ingredients with clinically proven results. We love sharing all the nerdy details, so if you're not into it, just skip the next part
Reduces NF-kB activation
The NF-kB signalling pathway is involved in immune regulation and contributes to the inflammageing process. Therefore, we aimed to investigate the effect of Chios mandarin extract on the key inflammatory regulator NF-kB in human dermal fibroblasts. For this purpose, cells were pre-treated in the presence and absence of Chios mandarin extract. Inflammation was then induced and active NF-kB was analysed.
Inflammation resulted in robust activation of NF-kB and its translocation to the nucleus. Pre-treatment with Chios mandarin extract significantly reduced NF-kB activation, demonstrating suppression of NF-kB signalling and, consequently, inflammaging.
Reduces Inflammatory Response
To investigate the effect of Chios mandarin extract (CALmandrin™) on inflammation, in vitro studies were performed using keratinocytes and dermal fibroblasts. For the keratinocyte assay, cells were treated with an inflammatory cocktail to stimulate chronic inflammation in the presence and absence of Chios mandarin extract.
Analysis of genes essential for the inflammatory response revealed that Chios mandarin extract decreased the expression of inflammatory markers in keratinocytes. In a second assay, dermal fibroblasts (skin) were treated with the secretion of UV-stressed keratinocytes to simulate inflammaging conditions in the presence and absence of the Chios mandarin extract. Again, analysis of genes showed that the inflammatory response was reduced by treatment with Chios mandarin extract, representing an anti-inflammatory effect.
CALmandrin™ Extract Increases Young Collagen
Since the inflammatory response was reduced in keratinocytes and dermal fibroblasts (skin), we wanted to test whether Chios mandarin extract affected collagen deposition.
Therefore, dermal fibroblasts were stressed with H2O2 in the presence or absence of Chios mandarin extract. Oxidative stress decreased the secretion of procollagen, whereas treatment with Chios mandarin extract counteracted this effect and increased the procollagen released compared with the stressed control.
In addition, an ex vivo study was performed on skin explants with a cream containing 2% CALmandrin™ or the corresponding control. The treatment with CALmandrin™ for seven days showed a visible increase in the ratio of young to mature collagen.
CALmandrin™ Soothes Reddened and Irritated Skin
To show the calming and rejuvenating effect of CALmandrin™, a randomized placebo-controlled clinical study was conducted on a panel of volunteers with signs of skin redness and photo-ageing. Twenty women aged between 51 and 68 years (mean 60.9 years) applied a cream containing 2% CALmandrin™ or a corresponding placebo on each side of their face and on two separate areas on the forearms twice daily for 28 days. CALmandrin™ showed a visible improvement in skin redness by −15.9% compared to initial conditions. Interestingly, facial skin redness was already decreased after 7 days of CALMandrinTM- treatment demonstrating a fast-acting effect on reddened skin.
CALmandrin™ Rejuvenates The Skin
In addition to skin redness, the effect of CALmandrin™ on signs of ageing was investigated on the same panel of volunteers. Treatment with 2% CALmandrin™ increased skin elasticity by 29.5% and 29.3% after 7 and 28 days compared to initial conditions. Furthermore, CALmandrin™ enhanced skin firmness by 13.9% and 16.9% after 7 and 28 days, respectively.
Only 7 days of CALmandrin™ application enormously improved skin elasticity and firmness, highlighting a rapid improvement of the skin parameters. Besides skin firmness and elasticity, 2% CALmandrin™ significantly improved skin density measured on the forearm by 11.1% after 28 days of treatment compared to initial conditions.
eyeam products containing CALmandrin™
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